Posted on

Immune checkpoint inhibitor therapy linked to higher incidence of cardiovascular events

hemonc today logo

September 07, 2022

2 min read

Laenens reports no relevant financial disclosures. Please see the study for all other authors’ relevant financial disclosures.

We were unable to process your request. Please try again later. If you continue to have this issue please contact

Immune checkpoint inhibitor therapy appeared associated with an increased risk for major adverse cardiovascular events among patients with cancer and a prior history of cardiovascular disease, according to results of a retrospective study.

The findings, published in Journal of Clinical Oncology, suggest routine thorough cardiovascular history, electrocardiography and echocardiography might identify patients who need regular cardiovascular follow-up during and after immune checkpoint inhibitor treatment, researchers noted.

Among patients with cancer who received immune checkpoint inhibitors
Data derived from Laenens D, et al. J Clin Oncol. 2022;doi:10.1200/JCO.21.01808.


Immune checkpoint inhibitors (ICIs) have been known to cause immune-mediated myocarditis in some patients. However, incidence of other major adverse cardiovascular events after ICI therapy remains unknown, according to study background.

“The current literature on cardiovascular toxicity of ICIs consists mainly of case series,” Dorien Laenens, MD, cardiologist in the department of cardiology at University Hospitals Leuven in Belgium, and colleagues wrote. “Another limitation of the currently available data is that randomized clinical trials of ICIs focus on survival, response and disease control, usually [during] short follow-up periods.”

To address the lack of knowledge, researchers collected data from digital patient files of University Hospitals to identify incidence of and risk factors for major adverse cardiovascular events among 672 patients (median age, 65 years; 64.7% men) with cancer treated with ICIs, and compared incidence rates with patients with cancer not treated with ICIs and population controls after matching according to age, sex, cardiovascular history and cancer type.

Major adverse cardiovascular events — a composite of acute coronary syndrome, heart failure, stroke and transient ischemic attack — served as the primary endpoint. Acute coronary syndrome and heart failure served as secondary outcomes.

Median follow-up was 13 months (interquartile range, 6-22).


Overall, 572 patients received only one line of ICI therapy, 90 patients received two lines of therapy, eight patients received three lines and two patients received four lines. More than half of patients (54.9%) died — with 1.9% deemed cardiovascular deaths.

Researchers reported a 10.3% incidence of major cardiovascular events, with a median time to event of 5 months.

Results of multivariable analysis showed having a history of heart failure (HR = 2.27; 95% CI, 1.03-5.04) and valvular heart disease (HR = 3.01; 95% CI, 1.05-8.66) remained significantly associated with major adverse cardiovascular events.

“Cumulative incidence rates were significantly higher in the ICI group compared with the cancer cohort not exposed to ICI and the population controls, mainly driven by a higher risk of heart failure events,” the researchers wrote.


The findings reinforce the clinical relevance of a cardiovascular workup of patients with cancer before exposure to ICI treatment, particularly in those with preexisting cardiovascular disease, the researchers wrote.

“Prospective or retrospective all-comer studies with bigger cohorts are essential for capturing true incidence of major cardiac events in daily practice,” they continued.

“Concomitant cardiovascular disease is often an exclusion criterion in clinical trials. This might be one of the reasons why this type of toxicity is underreported in phase 3 trials. In addition, toxicity is often not part of the follow-up when treatment within the context of the study is ceased. Cohort studies like ours can compensate for these shortcomings.”

Posted on

ITF Women’s 60k and 100k events highlights of Performance Competitions Calendar for Autumn and Winter 2022

ITF Women’s 60k and 100k events highlights of Performance Competitions Calendar for Autumn and Winter 2022

We have today confirmed dates for its Performance Competition Calendar for the remainder of the 2022 season. A comprehensive programme of tournaments until December has been announced for both adults and juniors in all categories.

Highlights include Great Britain hosting ITF World Tennis Tour (WTT) Women’s $100K and $60K events, both on indoor hard courts, in Shrewsbury and Glasgow, respectively.

There are further ITF World Tennis Tour (WTT) Men’s $25K events taking place in Sheffield, Sunderland and Glasgow in October and a Women’s $25K event in Loughborough the same month. Abingdon will host an ITF Wheelchair Tennis Tour Futures event in October, with the Wheelchair Tennis National Finals to take place at the start of December.

Professional event calendar

  • M25 Sheffield – w/c 3 October
  • M25 Sunderland – w/c 10 October
  • W60 Glasgow – w/c 17 October
  • M25 Glasgow – w/c 17 October
  • ITF Futures – w/c 17 October
  • W25 Loughborough – w/c 24 October
  • W100 Shrewsbury – w/c 31 October
  • Wheelchair Tennis National Finals – w/c 28 November

Check out the full calendar here

The 14U calendar features the new Junior Home Nations event in the week commencing 26 September, as well as in Nottingham the week commencing 24 October followed by the season-ending Tennis Europe Junior Tour category 3 event in Liverpool the week commencing 7 November.

For 12 and under players there will be Junior Home Nations events and Nationals (at Bolton and Corby) in the same weeks as the 14U events. There will also be a Tennis Europe Category 1 event in Bath the week commencing 31 October.

Finally, for 10U players there will be a National Tour event in the autumn in Sunderland and the 9U players will have National Tour events at either the National Tennis Centre or Loughborough University.

The Performance Competitions Calendar is designed to provide significantly enhanced opportunities for British players at each age and stage of the player pathway. Once the season concludes in December, we will have staged a total of 98 international events for age groups from 10U to pro-players on British soil (excluding traditional grass court season events) throughout 2022. This is a percentage increase in tournaments of 139% since 2019.

Posted on

FIFA introducing World Cup Fan Fest events for Qatar 2022 and could see London bid to stage its own

FIFA has launched 'Fan Fests' for the 2022 Qatar World Cup this winter, which will be outside the host country for the first time, to make the tournament more accessible for football fans

FIFA has launched ‘Fan Fests’ around the world for the 2022 Qatar World Cup to make the tournament more accessible for football fans.

The competition, lasting a little less than a month from October-November this winter, will take place in the remote Middle Eastern peninsula. 

And global football’s governing body FIFA is introducing fan parks outside the host country for the first time, to allow supporters to drink in the World Cup experience outside Qatar – and London could bid to host its own.

FIFA has launched 'Fan Fests' for the 2022 Qatar World Cup this winter, which will be outside the host country for the first time, to make the tournament more accessible for football fans

FIFA has launched ‘Fan Fests’ for the 2022 Qatar World Cup this winter, which will be outside the host country for the first time, to make the tournament more accessible for football fans

If London does secure its own venue, it would be competing with the hugely popular Winter Wonderland in the city centre around the same time. 

Officially licensed Fan Fests began at the Germany World Cup in 2006 and have continued since then. 

There were 11 festival parks across each of the host cities in the competition’s last edition, in Russia in 2018, and the previous four World Cups have seen 40million visitors across five continents.

FIFA President Gianni Infantino said: ‘To support our mission to make football truly global, accessible and inclusive, we are thrilled to introduce a new vision for the entertainment experience surrounding future FIFA World Cup events.

Official Fan Fests began at the Germany World Cup in 2006 and have continued since then, with 11 festival parks across each of the host cities in the last edition, in Russia in 2018

Official Fan Fests began at the Germany World Cup in 2006 and have continued since then, with 11 festival parks across each of the host cities in the last edition, in Russia in 2018

‘The FIFA Fan Festival provides an incredible opportunity for fans to come together beyond the stadiums and the on-pitch action and experience football in new and unique ways. 

‘We are truly excited about the future of the FIFA Fan Festival and the enhanced entertainment offerings that will bring fans and partners alike closer to both men’s and women’s FIFA World Cups, as well as global football culture.’

The fan parks at the Euro 2020 tournament, held across 11 countries in Europe, were largely successful, and the demand for tickets to the fan park in Hyde Park, London for the 2018 World Cup semi-final between England and Croatia was massive.

Qatar, a smaller country by area than Vanuatu, the Falkland Islands and Moldova , will only host one fan park, a ‘reimagined’ space in Al Bidda Park in Doha, with the capital city’s skyline in the background.

FIFA President Gianni Infantino (pictured) called the fan parks a 'new vision for the entertainment experience' in order to 'make football truly global, accessible and inclusive'

FIFA President Gianni Infantino (pictured) called the fan parks a ‘new vision for the entertainment experience’ in order to ‘make football truly global, accessible and inclusive’

It will feature live broadcasts of every match on giant screen, concerts with top global music artists, a food court with ‘local cuisine and international delicacies’, matches with FIFA Legends, gaming stations and an official FIFA store.

The country is inaccessible compared to previous editions of the World Cup, with costs expected to be high.

If an England fan travels return from London, follow the Three Lions’ to the final (if they get there) and attend all eight matches along the way, sit in the cheapest seats and stay in the least expensive accommodation, the Football Supporters’ Association has calculated you will part with £5,000, before you pay for any food and drink.

However, this has to be caveated with the fact tickets sales have been strong, with nearly 2.5million sold so far.

FIFA will be offering fans a chance to camp at the World Cup in tents costing £350 per night

FIFA will be offering fans a chance to camp at the World Cup in tents costing £350 per night

Supreme Committee for Delivery & Legacy Secretary General H.E. Hassan Al Thawadi added: ‘It will be the centrepiece of our FIFA World Cup – the first to be held in the Middle East and the Arab world. 

‘When fans arrive in November, they should expect a warm welcome, amazing football and a large number of entertainment options. We look forward to welcoming the world in just over 70 days.’

The Fan Fest will appear at the 2023 Women’s World Cup, held in Australia and New Zealand, for the first time.

In July, FIFA unveiled a ‘tent city’ offering accommodation for the World Cup, which will cost supporters £350 per night as part of a ‘fan village’ camping experience. The tournament, at the time of writing, will take place in 75 days. 

Posted on

11 events to accompany Smithsonian exhibition in Essex

11 events to accompany Smithsonian exhibition in Essex

11 events to accompany Smithsonian exhibition in Essex | News |  Gloucester Daily Times

Posted on

Russia-Ukraine war: List of key events, day 196

Russia-Ukraine war: List of key events, day 196

As the Russia-Ukraine war enters its 196th day, we take a look at the main developments.

Here is the situation as it stands on Wednesday, September 7.


  • United Nations chief Antonio Guterres has urged Russia and Ukraine to agree to a demilitarised perimeter around the Russian-held Zaporizhzhia nuclear power plant.

  • Russia’s Gazprom says it has signed an agreement to start switching payments for gas supplies to China to yuan and roubles instead of dollars.

  • Myanmar has started buying Russian oil products and is ready to pay for deliveries in roubles; the RIA news agency cited military ruler Senior General Min Aung Hlaing as saying.


  • The Russian-installed commandant of a southern Ukrainian city was seriously wounded in a blast, an official said, the latest in a series of apparent assassination attempts in occupied areas.

  • Ukrainian forces attacked the Russian-held eastern town of Balakliia in the Kharkiv region, according to a senior pro-Moscow separatist official, as Ukrainian officials were coy about how a counteroffensive was faring.

  • Speaking to Ukrainian television, the governor of the Luhansk region said, without giving locations, that a “counterattack is under way and … our forces are enjoying some success. Let’s leave it at that.”

Diplomacy and politics

  • Russia could be about to buy “literally millions” of artillery shells and rockets from old Cold War ally North Korea, the White House has said.

  • Russia questioned a UN-brokered deal with Ukraine to boost grain and fertiliser exports by both countries, accusing Western states of failing to honour pledges to help facilitate Russia’s shipments.

  • The United Kindgom’s new prime minister, Liz Truss, spoke with Ukrainian President Volodymyr Zelenskyy in her first call with a foreign leader and accepted an invitation for her to visit Ukraine.

  • Russia has not taken any steps to change an UN-brokered deal to facilitate grain exports, Ukraine’s agriculture minister said after Russian President Putin suggested routes should be changed.


  • The head of Russia’s VTB Bank has said the banking sector had largely overcome the most serious effects of Western sanctions and that systemic capitalisation of Russian banks was likely not needed.

  • The United States Treasury is seeking to design a simple compliance regime for enforcing a price cap on Russian oil exports and hopes that China and India join the coalition or at least take advantage of it, Deputy Secretary Wally Adeyemo said.

Posted on

Quadient among Finalists for Reuters Events 13th Annual Responsible Business Awards

Quadient among Finalists for Reuters Events 13th Annual Responsible Business Awards

Paris, September 7, 2022

Quadient (Euronext Paris: QDT), a leader in helping businesses create meaningful customer connections through digital and physical channels, announced today the company has been named a finalist for the Reuters Events 13th Annual Responsible Business Awards, in the Diversity, Equity & Inclusion category.

The Responsible Business Awards recognize and celebrate leaders in sustainable businesses that are positively impacting society, business and the environment. The award program serves as a benchmark for companies from across the globe looking to showcase leadership against international peers.

Quadient’s corporate social responsibility (CSR) strategy is built around five pillars: People, Solutions, Ethics & Compliance, Environment and Philanthropy. Highlights of the company’s inclusion and diversity initiatives include the signing and continued participation in inclusion and diversity charters, the deployment of an inclusion and diversity policy in 2021 and continuing to grow the company’s Empowered Communities program for all employees. The Empowered Communities program is open to all employees and provides safe places for open discussions and raising awareness around important inclusion and diversity topics.

We are excited to be shortlisted in the Responsible Business Awards, as Quadient’s employees and management team have been working collectively to create a more diverse and inclusive culture where everyone has equal opportunities for success,” said Brandon Batt, chief transformation officer and acting chief people officer for Quadient. Quadient’s CSR program remains at the heart of the company’s strategy as we continue to grow. Our commitment to improving Quadient’s inclusive culture positively impacts our relationships with all stakeholders, and in turn has helped the company to be recognized as an inclusive workplace by our employees, customers, partners, shareholders and analysts alike.

In recent years, Quadient’s CSR program and ESG practices have received various recognition from external rating agencies, including Vigeo Eiris, Gaïa Research, EcoVadis, CDP, ISS ESG and MSCI. The company was listed this year in the Global 100 Corporate Knights’ index of the world’s most sustainable companies. Quadient continues to focus on delivering profitable growth from its businesses in a sustainable and transparent manner through a comprehensive CSR program and in line with its commitment toward the UN Global Compact.

About Quadient®
Quadient is the driving force behind the world’s most meaningful customer experiences. By focusing on three key solution areas, Intelligent Communication Automation, Parcel Locker Solutions and Mail-Related Solutions, Quadient helps simplify the connection between people and what matters. Quadient supports hundreds of thousands of customers worldwide in their quest to create relevant, personalized connections and achieve customer experience excellence. Quadient is listed in compartment B of Euronext Paris (QDT) and is part of the SBF 120®, CAC® Mid 60 and EnterNext® Tech 40 indices.
For more information about Quadient, visit

Joe Scolaro, Quadient         

Sandy Armstrong, Sterling Kilgore

Global Press Relations Manager   Director of Media & Communications
+1 203-301-3673   +1-630-964-8500


Posted on

‘Doors Open Quinte West’ Returns September 10 with In-person Events

'Doors Open Quinte West' Returns September 10 with In-person Events

RELEASE — Doors Open Ontario, an Ontario Heritage Trust program, is returning for in-person events with Doors Open Quinte West on September 10 from 10 a.m. to 4 p.m. – the event is free of charge.

Collaborating with communities, Ontario Heritage Trust works to educate Ontarians about local history and conservation.

Each year, Doors Open Ontario offers Ontarians rare behind-the-scenes access to incredible cultural and natural heritage wonders. Doors Open Quinte West is excited to welcome people back by offering access to 14 cultural and heritage sites, with a mix of indoor and outdoor experiences.

Some sites include:

  • Research Casting International (10:00 a.m. to 4:00 p.m.): Research Casting International is one of the world’s largest providers of museum technical services – specializing in the fabrication of paleontology displays. They built skeletons of T-Rex’s for the original Jurassic park! Check out some of their current projects, explore their facility and watch the teamwork.
  • Crazy Creek Fishing Preserve (10:00 a.m. to 4:00 p.m.): In operation for over 25 years, this site provides public fishing, as well as a gathering space for barbeques, birthday parties and company get-togethers. Come and take a guided tour to view the 17 ponds – stocked with rainbow trout and speckled trout – set amid a cedar forest. This is a new site.
  • Quinte Museum of Natural History (10:00 a.m. to 4:00 p.m.): The Quinte Museum of Natural History has partnered with Research Casting International to bring Exploration Exhibits to the Bay of Quinte region. This series of dinosaur specimen displays was developed for international tour. This is a new site!
  • National Air Force Musuem of Canada (10:00 a.m. to 4:00 p.m.): Established in 1984, the National Air Force Museum of Canada is dedicated to preserving and telling the history of Canadian military aviation.

This event is one of many Doors Open Events happening this fall in the surrounding area. Why not take a day trip to visit Doors Open Kawartha Lakes (Sept. 11), Doors Open Belleville (Sept. 17), Doors Open Oshawa (Sept. 24) Doors Open Kingston (Sept. 24-25)?

These events make the perfect end of summer/fall road trip adventure – for other sites visit here and don’t forget to visit Digital Doors Open Ontario, which has over 250 sites to experience year-round.

Release: Submitted

Posted on

Green Guide for Events | City of Little Rock


In our studies, we have found that the simplest measures are the most effective ones. We encourage all local events to start their journey Towards Zero Waste by focusing on the elimination of individual items of trash and single-use plastic from their event footprint. We strongly encourage anyone starting on this journey to focus wholly on each individual item and its total eradication before moving onto the next. Your vendors and attendees need realistic, achievable goals, and you must support them in their efforts while enforcing your guidelines. Volunteers will be a crucial component to your success, as they will be educators and enforcers on the day(s) of your event.



We have developed a 3-pronged approach to the creation of our sustainability guidelines:

What the event can do.
What the vendors can do.
What the attendees can do.

What the Event Organizer Can Do


Communicating your guidelines clearly and confidently to your vendors, attendees, and community is critical to your success. 


Share resources with your vendors, tips with your attendees, and use signage and volunteers on the day(s) of your event to help everyone succeed (and take lessons home that positively impact the community). 


Event organizers must be adamant about the sustainability goals and define a system for dealing with nonobservance (particularly with vendors). Use signage and volunteers on the day(s) of your event to enforce efforts.

What the Vendors Can Do


We all have to recognize that how we are packaging and selling products is mostly unsustainable. Take responsibility for your business and home, and realize that being a steward of the Natural State is for future generations and the convenience of today should not be first priority.


Respect the goals of the event and do your part when packaging and presenting your product. Imagine if you had to personally deal with all of the waste from your product – make it minimal, biodegradable, and/or easily recyclable.


We know that humans must curtail our single-use, convenience-driven lifestyles to expect a future home for their progeny. That being said, this is still a trend that is gaining much traction! Share your successes with your patrons, and you will both be gratified at buying your product!


What the Event Attendees Can Do


Share and support your efforts online and by word of mouth! Give plenty of opportunity for the community to engage and react to your sustainability goals.


On the day of the event, attendees must come prepared to meet your goals. By bringing their own vessels, saying no to straws, and separating waste properly, everyone will be contributing to keeping the Natural State litter-free.


Urge attendees and the community to take these lessons beyond your event. Challenge them with ways to think outside the “plastic box” and engage with them on their efforts as a follow up!

(Próximamente) Descarga el manual en español aquí.

Access the appendix here

For more information about these resources and how to use them, please contact Brittany Nichols, City of Little Rock Recycling and Sustainability Programs Educator, at 501-371-4646 or by emailing

Posted on

Entangled Events – Announcements – e-flux

Entangled Events - Announcements - e-flux

Curated by Céline Matter. 

In the midst of a pervasive distrust of reality, the field of the perceptible world is becoming ever more closely tied to subjective experience. Entangled Events brings together works by young artists active in Switzerland who examine this changing relationship in order to attempt a reconciliation instead of the progressive isolation. The works focus on the potential of not thinking in opposites but with them and in the space between. Through videos, installations and performative moments, the connections and entanglements of individual events are traced. Events, which in the works do not merge into static truths but into a constant process of becoming. The artists document and stage phenomena, demonstrating how singular moments are products of collective relationships while at the same time each collectivity is constituted by singular phenomena. In so doing, the artists draw attention to a shared world and its dynamic configuration.

Camille Aleña

b. 1986 in Fribourg, Switzerland, lives and works in London

Mohamed Almusibli

b. 1990 in Sanaa, Yemen, lives and works in Geneva

Camille Kaiser

b. 1992 in Geneva, lives and works in Geneva 

Roman Selim Khereddine

b. 1989 in Zurich, lives and works in Zurich

Natalie Portman

Art collective based in Zurich

Eva Zornio

b. 1987 in Arlesheim, Switzerland, lives and works in Geneva

For further questions please contact Céline Matter (=(c=c.charCodeAt(0)+13)?c:c-26);});return false”>matter [​at​] or Giovanni Carmine (=(c=c.charCodeAt(0)+13)?c:c-26);});return false”>carmine [​at​]

Entangled Events is supported by Pro Helvetia, Schweizer Kulturstiftung, Ernst Göhner Stiftung, Stiftung Temperatio, Walter- und Ambrosina-Oertli-Stiftung, Kanton Genf and Stadt Genf.

The Kunst Halle Sankt Gallen is supported by Stadt St.Gallen, Kulturförderung Kanton St.Gallen, Swisslos, Susanne und Martin Knechtli-Kradolfer-Stiftung, Ernst und Olga Gubler-Hablützel Stiftung, E. Fritz und Yvonne Hoffmann-Stiftung, Dr. Georg und Josi Guggenheim-Stiftung, Martel AG and Kulturförderung Appenzell Ausserrhoden. The educational programme is made possible by Raiffeisen.

Posted on

Atlanta History Center’s September events lineup announced

Atlanta History Center’s September events lineup announced

ATLANTA, Ga. (CBS46) – The Atlanta History Center has announced its full slate of events for September 2022. It’s headlined by an Author Talks event with photographer Tabitha Soren. Other Author Talks include Bill Browder and history author Jonathan Darman. There are plenty of events for school-age children as well.

Toddler Storytime: Falling for Fall

  • WHAT: The monthly program for young toddlers returns in September with a fall focus. The event will once again include arts and crafts projects and story time. Tickets begin at $8 for children ages six and up and $15 for adults. Children from ages one to five and museum members can get in free.
  • WHERE: Atlanta History Center
  • WHEN: Sept. 7, 10 a.m.

Author Talks: Jonathan Darman

  • WHAT: History author Jonathan Darman will join Author Talks to discuss his book Becoming FDR: The Personal Crisis that Made a President. The book chronicles how Roosevelt’s battles with polio helped create the man as he is seen in popular memory. The former Newsweek correspondent also wrote Landslide: LBJ and Ronald Reagan at the Dawn of a New America.
  • WHERE: Virtual
  • WHEN: Sept. 8, 7 p.m.

Homeschool Day: If These Walls Could Talk

  • WHAT: This month’s Homeschool Days event focuses on how history can be learned by visiting the places where it happened. Visitors will learn how history can be examined by visiting spaces and examining objects that the people of the past lived in and used. Tickets are $9 for children four and up and $15 for adults. Members and children under three are free.
  • WHERE: Atlanta History Center
  • WHEN: Sept. 15, 10 a.m.

Author Talks: Tabitha Soren

  • WHAT: The former MTV News, ABC News, and NBC News reporter will stop by Author Talks to discuss her project Surface Tension. She uses an iPad screen and an 8×10 film camera to capture images. Tickets for the event are $5 for members and $10 for non-members.
  • WHERE: Kennedy Theater
  • WHEN: Sept. 15, 7 p.m.

Author Talks: Bill Browder

  • WHAT: Author Bill Browder will discuss his book Freezing Order: A True Story of Money Laundering, Murder, and Surviving Vladimir Putin’s Wrath. Browder was one of Russia’s largest foreign investors until it all fell apart; his lawyer, Sergei Magnitsky, was murdered over his attempts to uncover a $230 million tax refund scheme and Browder decided to follow the money. It led right to Vladimir Putin. Tickets are $5 for members and $10 for non-members.
  • WHERE: Grand Overlook Ballroom
  • WHEN: Sept. 19, 7 p.m.